Search for Similar Articles Particularly, when ephedrine is combined with caffeine (coffee), itcan lead to significant cardiovascular, metabolic, and hormonal responses. WhileDDB notes the FDAs approvalofLHQWas a traditional herbal product that may helprelievefever, muscle soreness, stuffy and runny nose associated with Covid-19, the DDBalsobelievesinpreventing diversion and unsafe use and abuseof this product withouthampering theaccess toit. XLZ conceived of the study, and perform this review. To clear scourge and remove toxin, diffuse the lung and discharge heat. She can be reached atbandiolateresamayb@gmail.com. There are no comments yet. If use with the other drugs at the same time may occur drug interactions,details please consult your physician or pharmacist. The registered Chinese capsule Lianhua Qingwen that has been approved should have the FDAs labeling requirements written in English, Domingo said. 8600 Rockville Pike Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. TheDangerous Drug Board (DDB)considers ephedrine as a dangerous drug, andthose found to be sources are also classified as dangerous drugs. Effect of Lianhuaqingwen Capsule on lung index of mice infected with virus [J]. Measuring inconsistency in meta-analyses. Wang Y, Zhang D, Du G, et al. [34]. Some error has occurred while processing your request. Chinese Journal of pharmacology and toxicology 2015;29:2137. Middle East respiratory syndrome case diagnosis and treatment program (2015 Edition) [J]. Ahsan W, Javed S, Bratty MA, et al. It is also for prevention of low blood pressure during anesthesia. However, there are individual differences in the efficacy of traditional Chinese medicine compound Lianhua Qingwen, which makes the quality of evidence of clinical efficacy of traditional Chinese medicine low. 4.Patients with diabetes patients,high blood pressure, heart diseases, liver disease, kidney disease and other severe chronic diseases shall take medicine under guidance of physician. Zhong said that, according to the experiment,the Lianhua Qingwen Jiaonang capsule can weakly inhibit the virus and repair cell injuries and inflammation caused by the virus. Hongying Mo, Changwen Ke, Jinping Zheng, et al. The effect of Lianhuaqingwen Capsule on the expression of inflammatory factors and connexin in lipopolysaccharide induced acute lung injury mice [J]. Clinically, Lianhua Qingwen Capsule can be used in the treatment of cold, flu-induced bronchitis, pneumonia, COPD, interstitial pneumonia and other lung inflammation. All patients must be diagnosed with prediabetes by clearly defined or internationally recognized criteria. >10 to <14 years old: 3capsules x 3 times a day ( after breakfast, lunch and dinner).> 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). Third, the capsule can shorten fever & coughting time. Used in the patterns of heat toxin assailing the lung in influenza, manifested as fever or high fever, aversion to cold, muscular soreness, stuffy and runny nose, cough, headache, dry and sore throat, reddish tongue, yellow or yellow and greasy tongue coating. Chinese Journal of nosocomial infection 2015;25:7279. Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. Not suitable for long-term use. The treatment of influenza using the TCM patent product Lianhua Qingwen won the Second-class Prize of the National Science and Technology Progress Award in 2011. To consume within 2 weeks after opening. The Chinese embassy likewise advised the public to only purchase and consume authentic traditional Chinese medicine produced by qualified pharmaceutical manufacturers. For the treatment of influenza due to heat-toxic attack lung, syndrome see: fever or serious fever,aversion to cold, muscle soreness, stuffy nose, runny nose, cough, headache, throat dry and sore throat, red tongue, yellow or yellow greasy tongue coating and so on. The PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) checklist of this protocol is presented in PRISMA-P checklist. (Photo by WANG ZHAO / AFP). Avoid spicy & greasy food during medication. The course of treatment is 7-10 days for patients with mild and moderate COVID-19. Traditional Chinese medicine Lianhua Qingwen treating corona virus disease 2019(COVID-19): Meta-analysis of randomized controlled trials. All relevant data are within the article and its supporting information files. The protocol will be disseminated in a peer-reviewed journal or presented at a relevant conference. Because the epidemic situation is still ongoing, there are still clinical studies in progress. your express consent. System searches CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as ChiCTR, NTR and clinical Trials.gov. Because the novel coronavirus pneumonia has not yet been completely subsided, more large-sample clinical studies are still ongoing. 2022 Aug 19;27(16):5292. doi: 10.3390/molecules27165292. A: Before treatment; B: After treatment. Consultancy by Fixx Digital Choosing a selection results in a full page refresh. We will judge the each domain as low risk of bias, high risk of bias," or uncertain risk of bias" according to Higgins (2011), and pay particular attention to the risk of bias of cluster-randomised trials. Is there any notice for taking Lianhua Qingwen Capsules? In accordance with the usage and dosage,the product should not be long term used. For more information, please refer to our Privacy Policy. All reports of the randomized controlled trials (RCTs) on Lianhua Qingwen capsule treating influenza [1] Over 200 countries and regions in the world have reported the confirmed cases successively, and become the global fast spread pandemic. Bias in. Federal government websites often end in .gov or .mil. It is based on the published clinical research literature at present stage. The two groups were compared in terms of clinical effects and main symptom (fever, cough and fatigue) disappearance rate. World Healthy Organization. 4 capsules per dose. [15]. Keywords: Race to find. All data generated or analyzed during this study are included in this published article [and its supplementary information files]. The .gov means its official. In 2013, Expert Consensus on Medical Treatment for Patients Infected with H7N9 Avian Influenza (2013), issued by the National Health and Family Planning Commission Sofia Tomacruz covers defense and foreign affairs. to maintaining your privacy and will not share your personal information without Lu Y, Zhang M, Yang QQ, Li WJ, Yang K, Hu W, Gao SY, Jiang QL, Lin LK, Cheng H, Sun F. Evid Based Complement Alternat Med. Consume daily after meal Primary Endpoints. In 2018, Diagnosis and Treatment Scheme for Influenza (2018), issued by the National Health and Family Planning Commission High-tech Demonstration Project of National Development and Reform Commission It is to systematically understand the curative effect of Lianhua Qingwen on the treatment of new crown pneumonia, and provide a reference for the design and follow-up work of the Chinese medicine compound Lianhua Qingwen in the global epidemic prevention and clinical trial design and follow-up work. 3.Patients with common cold due to wind-cold dont apply to the product. The data extraction form will include the following items: Two reviewers/authors (ZXL and ZQ) will independently evaluate the quality of the included trials through assessing the risk of bias using the following tools, when appropriate: The following aspects of included trials will be assessed: sequence generation, allocation concealment, blinding of participants, personnel and outcome assessors, incomplete outcome data, and selective outcome reporting. Why is it important to subscribe? Clearing away heat toxic materials,open the inhibited lung-energy and clearing away lung heat. Children should take under the supervision of adult. Risk ratio (RR) was used to express the severe conversion rate and CT improvement rate absorption rate; mean difference (MD) was used to express the time of fever reduction in secondary indexes; Odds Ratio (OR) was used to express clinical efficiency and symptom disappearance rate. [16] BMC Complement Altern Med 2017;17:130. 11. Wolters Kluwer Health The site is secure. The composition of Lianhua Qingwen granules is consistent with the pathogenesis of the disease. However, this systematic review will have some limitations. | 2023 ACTSmarket, capsules x 3 times a day ( after breakfast, lunch and dinner. Nguyen HT, Do VM, Phan TT, Nguyen Huynh DT. Aside from the Philippines, the Lianhua Qingwen Capsule has been approved in Hong Kong and Macau, Brazil, Indonesia, Canada, Mozambique, Romania, Thailand, Ecuador, Singapore and Lao. Please try again soon. Now. A few patients have cough, expectoration, chest distress, dyspnea, muscle ache, diarrhea, and other symptoms. The clinical data of 66 early-mid-stage COVID-19 patients admitted to hospitals in Guangzhou between January 2020 and April 2020 were retrospectively analyzed. Nevertheless, this systematic view should help further expand our understanding of Lianhua Qingwen combined with conventional antiviral Western Medicine treatments in COVID-19 and asymptomatic infection. Journal of Central South University for Nationalities: Natural Science Edition 2012;31:204. Highlight selected keywords in the article text. Put this medicine beyond the childrens reach. Learn more. All the prescriptions are used to clear the toxic heat in the lung, clear the lung qi, and cut off the disease. In WANFANG, novel coronavirus pneumonia, 2019-nCOV, COVID-19, and SARS-COV-2 were first searched for the keywords, then searched for the theme word Lianhua Qingwen and Lianhua Qingke. The 2 search were merged with the relationship. Novel coronavirus pneumonia is being set up by CNKI for the new research project. 3.2. The abstracts of all studies will be independently screened by the review authors (XLZand QL). Preliminary Study on the Inhibitory Effect of Lianhuaqingwen Capsule on Virus [D]. In comparison with the control group, 1) the total effective rate was significantly higher in the observation group (P<0.05); 2) the disappearance rates of fever, cough and fatigue were statistically higher in the observation group; 3) the treatment time was significantly shorter and patient recovery was significantly better in the observation group; 4) the laboratory index levels [white blood cell (WBC), interleukin-6 (IL-6), serum amyloid A (SAA)] were better in the observation group. In 2015, Diagnosis and Treatment Scheme for Cases Infected with Middle East Respiratory Syndrome (MERS) (2015), issued by the National Health and Family Planning Commission Keyword Highlighting As a drug, ephedrine is a decongestant and bronchodilator. Dont take this medicine if the description has changed. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. The Daily Guardian is a renascent Iloilo-based publishing firm and media outfit with bureaus in Kalibo, Boracay, Roxas, Bacolod, Antique, Guimaras, and Manila. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. Statistical heterogeneity will be assessed with the I2 statistic. 2020;99:30(e21404). Remdesivir in adults with severe, [13]. Early Treatment>14 years & above:4capsules x 3 times a day ( after breakfast, lunch and dinner) for7 to 10 days. WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba Preliminary study on the inhibitory effect of three prescriptions of traditional Chinese medicine on SARS related coronavirus in vitro [J]. Shunya Zhu, Xiaoying Li, Yunling Wei, et al. CT images of patient Mr. Lin (Male, Fifty-five years old) during different treatment periods. CT images of patient Mr. Lin (Male, Fifty-five years old) during different treatment, MeSH How to take it to realize the maximal efficacy? Guyatt GH, Oxman AD, Vist GE, et al. In addition, we learned from the experience of Rhubarb in the treatise on Febrile Diseases in the treatment of epidemic diseases. Statistical analysis was conducted by Revman 5.3 software. Effect of aqueous extract of Lianhuaqingwen Capsule on bacterial biofilm of methicillin-resistant Staphylococcus aureus [J]. [Package]Aluminium-plastic package, 24 capsules/box, [Executive Standard]Chinese Pharmacopoeia 2010, the 2nd supplemental volume. Web[Strength] 0.35g/capsule [Administration and Dosage] For oral administration, 4 capsules once, 3 times daily [Adverse Reactions] Unclear [Contraindications] Unclear [Precautions] 1. You may search for similar articles that contain these same keywords or you may Shunya Zhu, Xiaoying Li, Yunling Wei, et al. Select all eligible studies published before May 8, 2020. Ephedrine isanamphetamine-like compound, which is an addictive stimulant of the central nervous system. In addition, only studies published in English and Chinese will be searched and included because of language barriers, so a language bias may exist. SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD. Lianhua Qingwen, a representative TCM patent product for the treatment of influenza. Henan traditional Chinese medicine 2007;27:356. PMC [22]. Subgroup analysis and sensitivity analysis will be performed to explore the causes of heterogeneity. Medicine. Experimental study on the prevention and treatment of FM1 infected mice by Lianhuaqingwen capsule [J]. [28]. New Chinese medicine and clinical pharmacology 2007;18:69. Common side effects are heart palpitations, nausea, and vomiting. This product should not be used in treatment of wind-cold. [1014] Data showed that novel coronavirus pneumonia was confirmed in China, and 74,187 people used Chinese medicine, accounting for 91.5%, of which 61,449 in Hubei Province used Chinese medicine, accounting for 90.6%. LHQW is approved by China'sNational TCM Administration for the treatment of mild covid-19. Chest radiographs. Therefore, it is essential to perform a systematic review and meta-analysis to assess the effect of Lianhua Qingwen combined with conventional antiviral Western Medicine in clinical treatment of COVID-19 or asymptomatic infection. Your message has been successfully sent to your colleague. Dichotomous outcomes will be presented as risk ratio and 95% confidence intervals (CIs), and continuous outcomes will be presented as mean difference/standard mean difference and 95% CIs. All review authors critically reviewed, revised and approved the subsequent and final version of the protocol. Wang DC, Yu M, Xie WX, Huang LY, Wei J, Lei YH. For novel coronavirus pneumonia, the total effective rate of TCM is over 90%.[EB/OL]. Data curation: Xiaolin Zhang, Di Cao, Qi Zhang, Junnan Liu. Used in treatment of epidemic influenza and lung heat, symptom as fever or high fever, aversion to cold, muscular soreness, rhinostegnosis and nasal discharge, cough, headache, dry and sore throat, flushing tongue, or greasy fur of tongue. Avoid receiving nourishing Chinese medicine during the period in this product. Treatment of Sars-Cov-2: how far have we reached? Chinese Journal of viral diseases 2015;5:3524. [23]. Select all eligible studies published before May 8, 2020. We plan to carry out the following subgroup analyses if possible: the study area is different, the average course of disease is different, and the length of treatment is different. [Main Ingredients] BBD Aug 2024. Second Prize of National Science and Technology Progress Awards 5.Children, preganant or lactation women,elderly ,feeble and weak patients ,spleen and stomach weakness patients should be taken under the guidance of physician. The novel coronavirus pneumonia (COVID-19) has spread to >200 countries and regions. Even if symptoms of fever, fatigue and cough end earlier, please continue to complete an 8-day course to help the body recover.For children younger than 14 years old, we recommend that you consult a TCM physician on the dosage since the body condition differs from each child. government site. Chinese herbal medicine 2008;31:12303. Lianhua Qingwen combined with conventional antiviral Western Medicine may be a useful treatment for prediabetes. Philippines FDA approved LHQW for the treatment of mild Covid-19. [Drug Interactions]Interaction may appear if administered accompanied with other medicine, consult with doctors or pharmacists for details. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. Pharmacology and clinical research of traditional Chinese medicine 2010;26:214. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. WebDrug Name Lianhua Qingwen Capsules; Approval No. GYZZ Z20040063; Strength 0.35g/capsule; Administration and Dosage For oral administration, 4 capsules once, 3 Hongying Mo, Zifeng Yang, Jinping Zheng, et al. Click to view Lianhua Qingwen detailed prescribing information Overdosage View Lianhua Qingwen The COVID-19 may improve the clinical symptoms associated with fever, cough, and fatigue. Please abide by Rappler's commenting guidelines. Ends on 31 July 2022. Buy In 2005, Diagnosis and Treatment Scheme for Patients Infected with Avian Influenza (2005), issued by the Ministry of Health, Famous Kazakhstan journalist talks about Lianhua, New Progress in Study on Mechanism of Lianhua Qingwen Capsules for Treatment of COVID-19, TCM (Traditional Chinese Medicine) received by Cambodia for treating COVID-19 patients. The Authors. 7. The clinical effective rate, CT improvement rate, and severe conversion rate will be assessed as the primary outcomes. All tests are 2-tailed, and P < .05 is considered statistically significant. It includes forsythia, honeysuckle, ephedra (ma huang), armeniacae, gypsum, isatis, dryopteridis, houttuynia, pogostemon, rheum, rhodiola, Chinese peppermint (bohe), and liquorice. A: CT at admission (February 14, 2020); B: CT Reexamination after treatment (February 25, 2020); C: CT Reexamination after treatment (March 13, 2020); D: CT Reexamination after discharge (June 11, 2020). [25]. WebDosage/Direction for Use 4 cap tid w/ warm water. 6.Patients with fever over 38.5 , should go to the hospital. In particular, theChinese herbma huang, scientifically known asEphedra sinica, is where the drug ephedrine is extracted from. The DDB, however, had no objections to the product registration ofLHQWwith the Philippine FDA and said that the importer or distributor shall secure the proper license from thePhilippine Drug Enforcement Agency (PDEA) and comply with all regulatory requirements and relevant issuances. FREE SHIPPING within SG when you buy 4 boxes or more. Pharmacological experiments have indicated that a high dosage of Lianhua Qingwen alters the effectiveness of cyclooxygenase-2 in the arachidonic acid metabolic pathway and Bookshelf In this study, 100 participants were Do not use this product if the property changed. Patients with body temperature higher than 38.5 should see the doctor. It is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. If you are using other drugs, please consult your doctor before using this product. World Healthy Organization. In China, lianhua qingwen is recommended for treating thepneumonia. ACTSmarket.com is the e-shop and distribution arm of ACTSmarket Ltd, This site needs JavaScript to work properly. Chinese drug Lianhua Qingwen is one of 3 treatments which are part of Chinas standard therapy for mild and moderate coronavirus patients. [19]. Biotechnology communication 2003;14:3902. If I2 test <50%, a fixed-effects model will be used to pool the data. [Manufacturer]Company name: Shijiazhuang Yiling Pharmaceutical Co., Ltd. For RCTs, the Cochrane Collaboration's tool for assessing risk of bias will be used; 2. WebLianhua Qingwen Jiaonang with Chinese Characters; As per continuing post-marketing surveillance, there is still incessant sale and distribution even through social media platforms, such as Facebook, of Lianhua Qingwen Jiaonang with Chinese characters, which were verified as unregistered by the FDA. Copyright Shijiazhuang Yiling Pharmaceutical Co,Ltd. Experimental study on the anti Coxsackie B4 virus effect of Lianhuaqingwen capsule [J]. Abbreviations: BAs = comparison before and after the study, C0VID-19 = Corona Virus Disease 2019, ChiCTR = China Clinical Trial Registration Center, MERS = Middle East respiratory syndrome, NOS = Newcastle Ottawa scale, NTR = Netherlands National Trial Registration Center, PRISMA-P = Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, RCTs = randomized controlled trials, RCSs = retrospective cohort study. The proportion of severe patients admitted to covid-19 hospital is 15.7%, and the death rate of confirmed patients is 6.7%. [21]. To systematically determine the effect of Lianhua Qingwen Capsules on the early antiviral and anti-inflammatory action against COVID-19 (Coronavirus 2019) and its applicational value in the treatment of COVID-19. 9 Experimental research also showed that LH exerted broad-spectrum effects on a series of influenza viruses by inhibiting viral propagation and regulating immune function. [35]. It is compatible with Rhodiola to clear lung and remove blood stasis. Used for patterns of heat toxin assailing the lung in flu, manifested as fever, aversion to cold, muscle soreness, stuffy & runny nose, cough, headache, dry & sore throat, reddish tongue, yellow & greasy tongue coating. Also illustrates the potential biases within each of the included studies by presenting a risk of bias," table, graph, and summary. doi: 10.1097/MD.0000000000021404. Removes heat-toxin invasion of the lungs, including symptoms eg, fever, aversion to cold, muscle soreness, stuffy & runny nose. Here, we chose a thirteen-component TCM formula, Lianhua Qingwen capsule (LHQW), as a XLZ and QZ will independently screen the potential studies and extract data. A funnel plot will be constructed and examined to assess publication bias and possible small study biases if the group include more than 10 trials. WebAs chemical analysis for quality control (QC) of traditional Chinese medicine (TCM) formula is difficult to guarantee the effectiveness, a bioassay method that combines QC with evaluation of therapeutic effects has been developed to assess the TCM quality. China's top respiratory expert, the leader of the high-level expert group of the National Health Commission, Zhong Nanshan said in a webinar with overseas Chinese students, Lianhua Qingwen capsule has been proven effective for the treatment of virus. In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. It is not necessary for ethical approval because this article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors. Any disagreement will be resolved by consensus or discussion with a 3rd party (MJL). The Chinese embassy in the Philippines announced this on Wednesday, August 12, hailing it as an important progress in the entry of TCM products into the Philippine market.. In 2010, Diagnosis and Treatment Scheme for Wind-warm Lung-heat Disease (Non-severe Community Acquired Pneumonia) (2010), issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine A: Chest radiograph of normal people; B: Chest radiograph of a patient with early-mid-stage COVID-19. The rate of positive nucleic acid detection of COVID-19 from intranasal and pharyngeal swabs was significantly lower in the treatment group Already have Rappler+? Hai Guo, Jin Yang, Jiening Gong, et al. [33]. Novel coronavirus pneumonia treatment plan (revised version 7) [EB/OL]. Infants / children aged below 4 years are not recommended to consume. PLoS One. [30] The I2 statistic of <50% indicates a low level of statistical heterogeneity, and that of 50% will be considered substantial statistical heterogeneity. [2]. Molecules. Kupferschmidt K, Cohen J. Siwen Tang, Yanfen Zhang, Kejian Liu, et al. If meta-analysis is not applicable, we will conduct a systematic narrative synthesis providing information to summarize and explain the characteristics and findings of the included studies. Before the evaluation results of this system are published, all databases will be retrieved again. PRISMA flow diagram of study and exclusion. 2022 Jan;20(1):26-33. doi: 10.1016/j.joim.2021.10.005. Disclaimer. Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. If there are latest published studies, they will be directly included in the comprehensive treatment together with previous studies. WebChronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory response that is worsened by acute exacerbations. The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. In the fifth edition of COVID-19's diagnosis and treatment guideline issued by the China Health Commission, LHQWG is listed as one of the recommended medicine The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in Led by Iloilos most respected journalists, the Daily Guardian pledges to tell the Ilonggo story as seen through the various lenses of society so that every side may be told. It cannot be bought over-the-counter and not recommended for self-medication. [17]. Consult with doctors or pharmacists before administration if other medicines are received during this time. FDA Phase-II Clinical Study, In 2020, Diagnosis and Treatment Scheme for Novel Coronavirus Pneumonia, jointly issued by the Chinese Health Protection Committee and the State Administration of Traditional Chinese Medicine [Administration and Dosage] [36]. https://news.cgtn.com/news/2020-04-16/Beijing-approves-TCM-drugs-for-COVID-19-PJWgGfRAQg/index.html. If substantial heterogeneity is identified, we will report it and explore possible causes using sensitivity analysis and subgroup analysis.
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