COVID-19 vaccination of individuals with Down syndromedata from the Trisomy 21 Research Society Survey on safety, efficacy, and factors associated with the decision to Be vaccinated. Motor palsies of cranial nerves (excluding VII) after vaccination: reports to the US vaccine adverse event reporting system. Link between peripheral neuropathy symptoms and COVID vaccine The outcomes of interest were to compare BP incidence among (1) SARS-CoV-2 vaccine recipients, (2) nonrecipients in the placebo or unvaccinated cohorts, (3) different types of SARS-CoV-2 vaccines, and (4) SARS-CoV-2infected vs SARS-CoV-2vaccinated individuals. It can affect the PNS. The intranasal inactivated influenza vaccine was suggested to be strongly linked with BP through mediating inflammation due to containing Escherichia coli heat-labile enterotoxin. COVID-19; adverse effects; cranial nerve palsies; vaccination. The included studies for quantitative synthesis were pooled within 4 sections. J AAPOS. , Patone Vaccines for COVID-19. X, Visit our coronavirus hub for the most recent information on the COVID-19 pandemic. COVID-19 Vaccine Side Effects J, M, Given that COVID-19 has caused many deaths, the protection that vaccines can offer outweighs the potential for rare harmful effects. et al. Z, et al; contributors from the Global COVID-19 Neuro Research Coalition. B. COVID-19: Long-term effects - Mayo Clinic et al; COVID-NET Surveillance Team. M. TH, Haddix , Wong Vaccines against the coronavirus will have side effects - PBS Bell palsy (BP), also known as idiopathic facial nerve palsy, is the most prevalent cause of acute spontaneous peripheral facial paralysis, with a reported annual incidence rate of 15 to 30 cases per 100000 population.1,2 Although the exact cause of BP is unclear, viral infections (such as herpes simplex virus), ischemia, and inflammation are some of the suggested underlying mechanisms.3 Notably, BP is also reported following SARS-CoV-2 infection.4 COVID-19, caused by SARS-CoV-2, is a contagious respiratory syndrome with a wide range of manifestations, from asymptomatic and mild infection to hospitalization and death,5 as well as a wide variety of neurologic manifestations.6. Quality Assessment of the Self-controlled Cases Series Studies Using the Newcastle-Ottawa Scale (NOS) Modified for Self-controlled Cases Series Studies, eFigure 1. , Hls No, brain aneurysms are not a common side effect of COVID-19 VK, Peixoto , Greenland G. R, Hukkanen KTK, Xiong [9] https://assets.publishing.service.gov.uk/government/uploads/system/uploa However, the surrogate studies using similar formulations by Pfizer [8] and Moderna [9] did confirm a biodistribution of mRNA vaccines beyond the injection site. M, https://imagebank.hematology.org/image/60670/ependymalcellsincerebros NCI CPTC Antibody Characterization Program. The analysis of observational studies shows that the odds of BP incidence after SARS-CoV-2 mRNA vaccines did not significantly differ from those who did not receive any vaccine. These include: Although the above factors have an association with the vaccines, factors unconnected to the vaccine may be responsible for or contribute to peripheral neuropathy. However, no association between the mRNA vaccines and BP was seen in the observational studies. This systematic review and meta-analysis of pooled randomized clinical trials found that the incidence of BP was significantly higher in vaccine vs placebo recipients. sharing sensitive information, make sure youre on a federal Case reports of acute transverse myelitis associated with mRNA vaccine for COVID-19. E, U, Ludvigsson The meta-analysis was composed of 2 subgroups of mRNA vaccines (Pfizer/BioNTech and Moderna) and viral vector vaccines (Janssen and Oxford/AstraZeneca) (Figure 1). Aims of the study: MF, O. O, Abu-Full J Family Med Prim Care. Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden. In rare cases, the following conditions have occurred after COVID-19 vaccination: One of the neuropathies with a link to the COVID-19 vaccine is GBS, a rare condition in which the immune system damages nerve cells. Nerve damage, including peripheral neuropathy Fatigue and post-exertional malaise Cognitive impairment/altered mental state Muscle, joint, and chest pain Recently, vaccine distribution to the vasculature and interaction with circulatory platelets have been proposed as a likely mechanism for thrombosis with thrombocytopenia syndrome (TTS) [6]. The quality of the studies was evaluated by the Newcastle-Ottawa Scale. R, Mishra Baugh et al. official website and that any information you provide is encrypted Rare Side Effects of COVID Vaccines Myocarditis and the COVID-19 Vaccines. JH, Kim The site is secure. 2023 Feb 1;6(2):e2253845. et al; European Headache Federation School of Advanced Studies (EHF-SAS). M, DArrigo Quality Assessment of the Randomized Controlled Trials Using the Cochrane Risk of Bias (ROB1) Tool, eFigure 3. , Yu S, Robins GBS is rare. References April 20, 2023. SA, Althaqafi Who Is Eligible for a Second Bivalent Booster? et al. Vaccine-induced immune thrombotic thrombocytopenia. All Rights Reserved, Challenges in Clinical Electrocardiography, Clinical Implications of Basic Neuroscience, Health Care Economics, Insurance, Payment, Scientific Discovery and the Future of Medicine, Published online April 27, 2023. doi:10.1001/jamaoto.2023.0160. OR indicates odds ratio; SIDIAP, Spanish database of Information System for Research in Primary Care. An official website of the United States government. VP. JTC, Tan AH, Noori , Lim PC, The TGA closely monitors reports of suspected side effects (also known as adverse events) to the Covid-19 vaccines. JL, Schultze However, age and the severity of facial paralysis based on the House-Brackmann scale may predict poor outcomes.27. HM, Baden Covid vaccine side effects Pfizer and BioNTech said Adverse reactions and safety profile of the mRNA COVID-19 vaccines among Asian military personnel. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Clinical features of varicella-zoster virus infection. JD, Khatkhate , Lai This study followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).31 The study protocol has been registered with PROSPERO (CRD42022313299). PRISMA Flow Diagram of the Systematic Search, eFigure 2. Guillain-Barr syndrome and vaccines. eCollection 2023. contributors from the Global COVID-19 Neuro Research Coalition, See this image and copyright information in PMC. Summary of the Studies Characteristics (Case Reports and Case Series), eTable 4. , Vilches COVID Vaccine Side Effects | Johns Hopkins Medicine While the Y, Kyoya AA. Published by John Wiley & Sons Ltd. With SARS-CoV-2 infection, however, the reported BP incidence is significantly higher at 32.3 to 82 per 100000 patients.55,57 These results overall suggest that the BP incidence after SARS-CoV-2 vaccines is comparable with the overall incidence in the general population, whereas it clearly exceeds that with SARS-CoV-2 infection. , Sohrabi Accessibility M, Lai ML. doi: 10.1001/jamaoto.2023.0160. , Lai Reports of Guillain-Barr Syndrome After COVID-19 Vaccination in the United States. S, Blackman . 2022 Jul;92(1):157-158. doi: 10.1002/ana.26369. The vaccine transfection and translation in the nerves may spur an immune response against nerve cells potentially resulting in autoimmune nerve damage. Significantly more neurological adverse events were reported following Janssen (Ad26.COV2.S) vaccination compared to either Pfizer-BioNtech (BNT162b2) or Moderna (mRNA-1273; 0.15% versus 0.03% versus 0.03% of doses, respectively,P<0.0001). Can COVID-19 vaccination lead to neurological complications? Burrows A, Bartholomew T, Rudd J, Walker D. BMJ Case Rep. 2021 Jul 19;14(7):e243829. The funnel plots for the publication bias are represented in eFigure 6 in Supplement 1. G, Carrafiello Data Extraction and Synthesis G. The Egger test yielded a P value of .64; hence, no publication bias was present. O, , Yalinda B, DG, Caete E, Ziaei Real-time analysis of a mass vaccination effort confirms the safety of FDA-authorized mRNA COVID-19 vaccines. , Shibli This will not only help in explaining a causal link but will also help take necessary precautionary measures in time for public safety. et al. Use or keep moving your arm. Accessibility Statement, Our website uses cookies to enhance your experience. 2023 American Medical Association. C, Dessypris One of the subjects was later diagnosed with multiple sclerosis [5], declared unrelated to the vaccine. -. JA, Tamborska GBS causes inflammation of the nerves and can lead to numbness, weakness and pain, usually in the feet, hands and limbs and can spread to the chest and face. Drs Rafati and Pasebani contributed equally to this work. People who had severe illness with COVID-19 might experience organ damage affecting the heart, kidneys, skin and brain. S, Rcker The CDC reports that COVID-19 vaccines are safe. The CDC does not list brain aneurysms as a common side effect after COVID-19 vaccination in any age group. The facial (cranial) nerves, on the contrary, are anatomically closer to the vaccine injection site in humans (deltoid muscle). SG. However, most scientific literature relates to a handful of cases, using case studies or case series. The occurrence of BP did not differ between recipients of the Pfizer/BioNTech and Oxford/AstraZeneca vaccines, and there was a greater risk of BP with SARS-CoV-2 infection compared with SARS-CoV-2 vaccination. MI, Katsanos Small fiber neuropathy as a complication of SARS-CoV-2 vaccinations. A 32-year-old psychologist in Britain developed blood clots and died 10 days after he took his first dose of AstraZenecas Covid and transmitted securely. , Palaiodimou Autoimmune damage to the nerves following Covid vaccines: EMA C, Persson , Eom NP, Lewis Federal government websites often end in .gov or .mil. Unauthorized use of these marks is strictly prohibited. The biodistribution (study 514559) also evidenced the vaccine distribution via blood circulation to other tissues notably bone marrow, liver, mammary glands and spleen. Jacobson EB, Dellis This heterogeneity could be attributable to different inclusion criteria or sampling methods. Epub 2021 Nov 18. , Sato Symptoms following COVID vaccination. doi: 10.1136/bcr-2022-253302. L. FY, Overall, 13518026 vaccine doses as the vaccinated group were compared with 13510701 matched unvaccinated individuals (Figure 2). G, Gil Daz Organ damage could play a role. Incidence Proportion of Bells palsy after SARS-CoV-2 Vaccines (Derived From RCTs). D, Please enable it to take advantage of the complete set of features! Bias and efficiency of meta-analytic variance estimators in the random-effects model. The association between COVID-19 vaccination and Bells palsy. There were at least 127 other instances of nerve injury and 301 cases of various forms of neuropathies (including 207 cases of peripheral neuropathy) listed in the MHRA database [2]. WebShingrix can make the area where you get the shot swell or feel sore. SARS-CoV-2 vaccination-induced transverse myelitis. T. Nath is convinced they are extremely rare. Long Covid, in contrast, affects anywhere from about 5% FH, I, Ortqvist No competing interests, Copyright 2023 BMJ Publishing Group Ltd. https://www.ema.europa.eu/en/news/meeting-highlights-pharmacovigilance-r https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine- https://www.fda.gov/media/150723/download. , Castaldo WebMultiple cranial nerve palsies following COVID-19 vaccination-Case report In our case, the most probable etiology of the patient's multiple cranial neuropathy is the Pfizer-BioNTech Bell palsy (BP) has been reported as an adverse event following the SARS-CoV-2 vaccination, but neither a causative relationship nor a higher prevalence than in the general population has been established. Vaccines (Basel). Vaccine Effect or Functional Neurological Disorder , Hamid FTT, Chua https://assets.publishing.service.gov.uk/government/uploads/system/uploa https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-ho https://doi.org/10.1101/2021.06.29.450356, https://www.medpagetoday.com/infectiousdisease/covid19vaccine/93537, https://casereports.bmj.com/content/bmjcr/14/4/e242956.full.pdf, https://onlinelibrary.wiley.com/doi/10.1111/ncn3.12537, Womens, childrens & adolescents health, Autoimmune damage to the nerves following Covid vaccines: EMA issued warning to patients and healthcare professionals. We report the case of a 29-year-old male patient with no notable history who presented with left oculomotor, abducens, trigeminal and facial palsies 6 days after receiving the first dose of the Pfizer-BioNTech COVID-19 vaccine. , Shasha There was, however, no significant increase in BP after administration of the messenger RNA SARS-CoV-2 vaccine in pooling 8 observational studies (13518026 doses vs 13510701 unvaccinated; OR, 0.70; 95% CI, 0.42-1.16; I2=94%). Lopez Bernal, J. et al. This article is protected by copyright. Cerebral venous sinus thrombosis after mRNA-based COVID-19 vaccination. et al. Clipboard, Search History, and several other advanced features are temporarily unavailable. Objective [2] https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine- Note that the rates of headache, fatigue, dizziness and syncope exceed the yaxis scale for the Janssen vaccine and event rates are listed above these bars. Reuters, "COVID vaccine injury plaintiffs face long odds in U.S. compensation program," June 16, 2022 Federal Aviation Administration statements, April 27 and April 28, 2023 Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, COVID-19 vaccine: What to do about side effects. All records included in the meta-analysis had NOS scores of 7 or higher. R, Charan , Page Rare Side Effects of COVID Vaccines Myocarditis and the COVID-19 Vaccines. Covid vaccine injury government site. Estimators of the Mantel-Haenszel variance consistent in both sparse data and large-strata limiting models. SINGAPORE: The family of a woman who died about four days after receiving a COVID-19 vaccine booster jab was given S$225,000 (US$169,122) under the Vaccine nausea. CC, Sokol Instead, they have reported the combined data, and their analyses were based on the events per vaccine dose and not based on the events per participant. A. [Color figure can be viewed at, Median time (days) from vaccine injection to adverse event onset, inclusive of all COVID vaccine types, and proportion of events which were reported after the first or second dose of a mRNA vaccine (using data available in 235,293/275,575 [85%] of patients who received either Pfizer or Moderna vaccines). Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barr Syndrome, February-July 2021. MT, Lee V, Michos Who Is Eligible for a Second Bivalent Booster? Evaluation of prognostic factors in patients with Bells palsy. Dashed line indicates the point estimate of the overall effect; dotted line, no effect; diamond, overall effect. Covid vaccine side effects: Tinnitus may be linked to inflammation , Tahir Is it possible to die from peripheral neuropathy? All Rights Reserved. Y. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. S, Kaur S, Badr-Eldin The MHRA pharmacovigilance database reported ~187 cases of sciatica post-Covid vaccine AZ as of 28th July 2021. SARS-CoV-2 infection posed a significantly greater risk for BP than SARS-CoV-2 vaccination. When attempting to compare with other vaccines and diseases, SARS-CoV-2 vaccine studies did not provide sufficient data for pooling. 2022 May;52(3):511-525. DG, Gtzsche Bells palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study. J, Zhang C, Coronavirus and the Nervous System | National Institute of J, NA, Harakeh 2023 Jan 20;11(2):236. doi: 10.3390/vaccines11020236. Other effects include: Many people who get the vaccine have muscle aches, headaches, or feel tired. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Phase 3 safety and efficacy of AZD1222 (ChAdOx1 nCoV-19) COVID-19 vaccine. Albakri K, Khaity A, Atwan H, Saleh O, Al-Hajali M, Cadri S, Diab RA, Albazee E, Negida A. SA, 2022 Mar;145(3):375. doi: 10.1111/ane.13561. This study has pooled data on more than 53 million vaccine doses for meta-analysis. (2023). P, Stahel They found an increased risk of haemorrhagic stroke, a brain bleed, in the 28 days after vaccination with the BioNTech/Pfizer shot, at an estimated 60 extra cases per 10m people. Most importantly, we used previously published data, and no individual patient-level data were available in this study. Incidence of Guillain-Barr syndrome after COVID-19 vaccination in the Vaccine Safety Datalink. A systematic search of MEDLINE (via PubMed), Web of Science, Scopus, Cochrane Library, and Google Scholar from the inception of the COVID-19 report (December 2019) to August 15, 2022. No evidence of pilots dying on flights from COVID-19 vaccine effects Can diet help improve depression symptoms? These autoimmune responses may well be transient in many healthy subjects, and the immune response is likely to be very selective towards vaccine transfected cells only, however, the possibility of developing a chronic autoimmune condition in some individuals cannot be overruled. Neurological side effects of SARS-CoV-2 vaccinations. The quality of the studies was evaluated by the Newcastle-Ottawa Scale. Incidence of Bell palsy in patients with COVID-19. et al. Is the incidence rate of Bell palsy (BP) following SARS-CoV-2 vaccination different from the incidence rate in those who have not received SARS-CoV-2 vaccines? To compare the incidence of BP in SARS-CoV-2 vaccine recipients vs unvaccinated individuals or placebo recipients. Before , Corra et al. N, Because of the high heterogeneity, a random-effects model was implemented, and a subgroup analysis was performed based on the study design (cohort or case-control study). Etiology of aseptic meningitis and encephalitis in an adult population. E, Levy Published online April 27, 2023. doi:10.1001/jamaoto.2023.0160. , Voysey 8600 Rockville Pike Four RCTs35-38,101 that reported BP as an adverse event were included in the first meta-analysis. The 50 included studies comprised 22 case reports and case series,30,60-80 2 SCCSs,54,81 2 case-control studies,39,40 3 cross-sectional studies,55,82,83 16 cohort studies,41-46,56,57,59,84-90 and 5 RCTs.35-38,58 A summary of the characteristics of the included studies is represented in the Table (case reports and case series are summarized in eTable 3 in Supplement 1) and detailed in eTable 2 in Supplement 1. Articles reporting BP incidence with SARS-CoV-2 vaccination were included. , Iftikhar Author Contributions: Drs Kheradmand and Rafati had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. et al. Individuals over the age of 65 can receive a second updated COVID-19 vaccineeither Pfizer or Moderna at least four months after their last updated dose. S. M, Cirillo 2022 Sep;11(9):5041-5054. doi: 10.4103/jfmpc.jfmpc_747_22. Results: 2022 Nov 7;13:921760. doi: 10.3389/fphar.2022.921760. W, Xu However, the rate of neurological events after acute SARS-CoV-2 infection was up to 617-fold higher than after COVID vaccination. JAMA 2021;326:16061613. D, Sullivan Notably, SARS-CoV-2 infection was linked with a 3.23-fold increased risk of BP compared with SARS-CoV-2 vaccines, which favors a protective role of the vaccine in reducing the incidence of BP associated with exposure to SARS-CoV-2. Articles reporting BP incidence with SARS-CoV-2 vaccination were included. , Repajic The most commonly reported symptoms of post- COVID-19 syndrome include: Fatigue Symptoms that get worse after physical or mental effort Fever Lung (respiratory) symptoms, including difficulty breathing or shortness of breath and cough Other possible symptoms include: , Singh , Tan Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine through 6 months. Quality Assessment of the Case Controls Using the Newcastle-Ottawa Scale (NOS) Modified for Case-Control Studies, eTable 6. The analysis of the observational studies showed that mRNA SARS-CoV-2vaccinated participants had no significant increase in BP incidence vs the unvaccinated participants.