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Tomar dosis muy altas de vitamina A o de isotretinona (un frmaco derivado de la vitamina A empleado para el tratamiento del acn grave) durante el embarazo puede producir defectos congnitos. Lee IM, Cook NR, Manson JE, et al. Vitamin E consumption and the risk of coronary heart disease in men. A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physicians' health study. La melanina puede reducirse a travs de distintas vitaminas. 1985;14:165-168. 2002;443(5-6):791-797. Aust.Fam.Physician 2007;36:1026-1028. 2002;27:5-7. Klin.Monbl.Augenheilkd. Contraindicaciones de la vitamina A Cochrane.Database.Syst.Rev. Betacaroteno, beneficios y propiedades para la salud - Natursan Ye, Z. and Song, H. Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies. Arch Intern Med 1996;156:637-42. Acta Paediatr. Minder, E. I., Schneider-Yin, X., Steurer, J., and Bachmann, L. M. 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