Youll receive Prolia doses from a healthcare professional. Prolia can also cause low calcium levels. The most common side effects of Prolia in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. 2023 Healthline Media LLC. Bone pain from Prolia may be most noticeable in your arms and legs. Before you have any dental work done, tell your dentist you are receiving this medicine. Do not use denosumab if you are pregnant. To date, the consensus is that there has been no proven risk of increased cardiovascular risk with intake of calcium supplements. High cholesterol levels can be a side effect of Prolia. They can tell you more about benefits and risks of Prolia and Forteo. Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. It is not known if the use of Prolia over a long period of time may cause slow healing of broken bones. This drug may decrease your body's ability to fight infection. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). It is not safe to receive Prolia during pregnancy. In certain cases, Prolia may have contraindications (not be recommended) for you due to a higher risk for side effects. This could include having: Before taking Prolia, share your dental history with your doctor. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. Prolia - Patient Information Leaflet (PIL) - (emc) - medicines * Symptoms can include: flushing (temporary warmth, redness, or deepening of skin color), swelling under your skin, typically in your lips, eyelids, feet, or hands, swelling of your mouth, tongue, or throat, which can make it hard to breathe. Specifically, Prolia is a monoclonal antibody (a lab-made protein). Copyright 1996-2023 Cerner Multum, Inc. Your risk of bone fractures can increase when you stop, skip or delay using Prolia. Your risk may also be higher if you: Stopping Prolia treatment can also increase your risk for bone fractures. But it can increase your risk of serious health problems, such as heart attack. You should not breastfeed while using this medicine. (Biosimilars are like generic drugs. WebYour doctor may prescribe calcium and vitamin D to help prevent low calcium levels in you With osteoporosis, your bones become porous, meaning there are large holes within your bone tissue. Continue reading. Some people have developed unusual fractures in their thigh bone. A healthcare provider will give you this injection in a hospital or clinic. Youll receive 60 mg/mL of Prolia once every 6 months. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. Prolia contains the active ingredient denosumab. Learn about the different options, including the benefits of each and any potential side, A FRAX score can help predict the risk of fractures in people with osteoporosis. You may need to go to the hospital for treatment. Last updated on Feb 8, 2023. The conditions and factors to consider include: Upcoming dental procedures. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). Call your doctor or health care professional if you are unable to keep an appointment. * In this article, we use the terms male and female to refer to someones sex assigned at birth. Generic name: denosumab (Prolia) [den-OH-sue-mab] Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. Also, its important to brush and floss your teeth regularly while youre using Prolia. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. Prolia If you have jaw pain or other mouth problems while youre using Prolia, tell your doctor or dentist. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. And some of these side effects are more common with certain uses of Prolia. * Sex and gender exist on spectrums. Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. These types of medications come in forms that are taken by mouth and forms that are given by injection. 8,432 people who take Prolia and Calcium together, and have interactions are studied. Prolia (denosumab) | Dosing Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Before starting Prolia treatment, talk with your doctor about any tooth procedures you have scheduled. There is a potential for serious side effects to an unborn child. The fractures may require surgeries, take several months to heal, or both. If you have osteoporosis or bone loss, your doctor may discuss Prolia as a treatment option. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. Find out what it means, how its calculated, and more. Now i'm wondering if i shouldn't take K2. Prolia can cause many serious side effects. Do not stop, skip or delay taking Prolia without first talking with your doctor. If youre concerned about hair loss with Prolia, talk with your doctor. If youre breastfeeding, you should not receive Prolia. Having dental procedures, including tooth extractions, during Prolia treatment may increase your risk of dental side effects. Do not share this medicine with another person, even if they have the same symptoms you have. Medically reviewed by Sanjai Sinha, MD. Calcium has active ingredients of calcium. This may help to protect healthy cells from damage. It comes as a liquid solution thats given as an injection. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. If youve already gone through menopause, your risk for bone loss is increased. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. Also describe any vitamins, herbs, or supplements you use. The use of the eHealthMe site and its content is at your own risk. If you want to stop taking Prolia, tell your doctor. Advertising on our site helps support our mission. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. You may also want to do some research on your own. Can diet help improve depression symptoms? For more information about how Prolia and Zometa compare with each other, see this article. What do I need to be aware of if I need a tooth extraction while Im using Prolia? Prolia is usually given once every 6 months. Its important to discuss all your concerns with your doctor. Its recommended that calcium and vitamin D supplements be taken (Biosimilars are like generic drugs. Learn strategies you can use today. Calcium Supplements If you keep this medicine at home, store it in the original carton in a refrigerator. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. And they want you to get the best care possible. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. These side effects may include: Its not known what percentage of people in clinical trials developed dental or jaw-related side effects. In addition, you should use effective birth control while youre taking Prolia. The Prolia is making my leg bones and jaw bones hurt. If you miss a dose of Prolia, you should receive your injection as soon as you can. This drug may not be the right treatment for your condition if you have certain medical conditions or other factors that affect your health. It works with your immune system to help prevent bone loss. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. You should not receive Prolia if you are allergic to denosumab, or if you Call your doctor for medical advice about side effects. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. Prolia can also cause bones to not form correctly and reduced growth in a fetus. Do not treat yourself. All rights reserved. Prolia These side effects may be temporary, lasting a few days or weeks. Side effects are possible with Prolia use, but in most cases they go away after a while. (To learn more, see the Precautions for Prolia section below.). We do not endorse non-Cleveland Clinic products or services. We study millions of patients and 5,000 more each day. Prolia should not be used during pregnancy. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. Some side effects of Prolia may go away on their own within a few days or weeks after starting treatment. Talk with your doctor before starting Prolia treatment. Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. You should not take Prolia if youve ever had an allergic reaction to Prolia or any of its ingredients. Patients should not stop Prolia treatment without first consulting your Last medically reviewed on November 29, 2022. What should I know about Prolia vs. Evenity? Continue reading, Yes, Prolia does appear to weaken your immune system. Get emergency medical help if you have signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). Theyll likely suggest other treatment options for your condition. After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. No, Prolia isnt a bisphosphonate. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more. Prescribing Information and (BMD is a measurement of the amount of minerals such as calcium in your bones.) Before you start Prolia treatment, your doctor will examine the inside of your mouth. Learn about compression fractures, preventive medications, and, Preventing osteoporosis can help you prevent fractures and maintain strength as you age. Biosimilars usually cost less than brand-name drugs. A healthcare provider will give you this injection. See what this means for you in the chart below. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. You may wonder how Prolia compares with the alternative drug Reclast. Doing so will help you avoid the risk for a low calcium level during treatment. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct You can learn more about how we ensure our content is accurate and current by reading our. Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. You should talk with your doctor if you develop any mild side effects that concern you. Other drugs that have the same active ingredients (e.g. This list doesnt include all possible mild side effects of the drug. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. for breast cancer that has not spread to other parts of the body. Weakness and tingling can also occur. You may report side effects to FDA at 1-800-FDA-1088. Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. If your levels are high, theyll typically recommend lifestyle changes and medication. Bring someone with you to your appointment if doing so will help you feel more comfortable. Serious infections may occur during treatment with Prolia. Try to avoid being around people who are sick. We avoid using tertiary references. Terms of Use. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. See your dentist regularly. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. They may help you identify other possible causes or suggest ways to help manage hair loss. Do not share this medicine with others. If you develop serious side effects while taking Prolia, call your doctor right away. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. Talk with your doctor about which other treatments are better choices for you. Prolia Forteo is given as a self-injection once daily. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases.