Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Not available for orders containing UltraNourish. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Silymarin is an active component of milk thistle, which is not found in foods. The irony of this list of side effects being associated with drugs intended to treat anxiety, depression, and OCD is not lost on us, and ultimately begs the question, What naturally helps OCD?. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. Eighteen clinical trials of 1,088 participants were assessed. There is a problem with 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y, Seeff LB, Curto TM, Szabo G, et al. privacy practices. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Milk thistle is a flowering herb native to Europe but is also found in parts of the United States, Australia, Asia, Africa, and South America. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. About curcumin, it isn't usually a problem but if you're on IMAOs you may like to read a bit before taking high doses. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. The benefits of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Copyright 1996-2023 Cerner Multum, Inc. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. 2008;47(2):605-12. doi:10.1002/hep.22044, Fried MW, Navarro VJ, Afdhal N, et al. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Effects of Silybum marianum (L.) Gaertn. Some people also call it Mary thistle and holy thistle. Milk thistle may interact with certain medications and supplements. People sometimes eat the stem and leaves of milk thistle in salads. More research is needed before a standard dosage of milk thistle can be recommended, so check with your healthcare provider. Some of the studies have been of poor quality, too. Combining silybin with phosphatidylcholine and other phospholipids enhances the absorption of milk thistle's active compounds, providing powerful liver health support. These products are not intended to diagnose, treat, cure, or prevent any disease. Bookmark the permalink. It can help prevent elevation of liver enzymes, which can be a side effect of the medication. Phytomedicine. 2020;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0206/jbcpp-2019-0206.xml. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. Luckily, more and more experts are turning to natural remedies to answer that question and circumvent the litany of side effects. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. Fluoxetine is whats known as a selective serotonin reuptake inhibitor (SSRI) which aims to increase serotonin levels in the brain. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. There is also concern that milk thistle might affect estrogen levels. However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations (44). Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. 5 It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. HHS Vulnerability Disclosure, Help This is especially important if you are taking any other medications for menopause or any blood thinners, such as statins. Osteoporosis is a disease caused by progressive bone loss. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. 2016;5147468. doi:10.1155/2016/5147468. Side effects. Minerals for OCD Milk Thistle. However, one area of milk thistle research focuses on how it affects bone marrow, which contributes to overall bone health but also has implications in treating diseases like multiple myeloma, a type of blood cancer. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. But the herb is also believed to be beneficial for other health issues. Researchers believe that silymarin reduced the oxidative stress traditionally attributed with diabetes (7). Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-B) pathway. 2 skintightspandex 3 yr. ago Ya idk I've taken milk thistle for liver health and I have anxiety independent of it Nootropicsfan 3 yr. ago Milk thistle supplements, for . From aloe to honey, you might be surprised what basic ingredients can help improve breakouts. include protected health information. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. We encourage you to discuss any decisions about treatment or care with your health care provider. J Diabetes Res. Epub 2019 Nov 24. However, its currently unclear if it has the same beneficial effects in humans. It is not intended to substitute for the medical expertise and advice of your health care provider(s). Milk Thistle Tea: Benefits, Side Effects, and Dosage - Healthline Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. You should not use this product if you are allergic to milk thistle or if you have: past or present cancer of the breast, uterus, or ovary; or. Abdulghani A, Poghosyan M, Mehren A, Philipsen A, Anderzhanova E. Front Mol Neurosci. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. 5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer's Disease Induced by D-Galactose and Aluminum Chloride. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Someone please correct me if I'm wrong. Talk to your doctor before taking any supplements because they might interfere with your medication. According to the International OCD Foundation about half of OCD patients stop taking their medications due to negative side effects. All rights reserved. Some people may be allergic to milk thistle. FOIA Medicinal use of this product has not been approved by the FDA. Milk thistle. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. 5 Brain Supporting Supplements Youll Want In Your Medicine, According to the International OCD Foundation, selective serotonin reuptake inhibitor (SSRI), UltraThistle, the highest potency milk thistle formula, Review on the Chemistry and Neuroprotective Effects of Silymarin. Milk thistle is generally considered safe when taken by mouth (1, 45). Amyloid plaques are sticky clusters of amyloid proteins that can build up between nerve cells as you age. In: Drugs and Lactation Database (LactMed). The mention of any product, service, or therapy is not an endorsement by NCCIH. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. CNS Neurosci Ther. Efficacy and safety of milk thistle preventive treatment of anti - LWW Milk thistle is taken by mouth most often for liver disorders, including liver damage caused by chemicals, alcohol, and chemotherapy, as well as liver damage caused by Amanita phalloides (death cap) mushroom poisoning, jaundice, chronic inflammatory liver disease, cirrhosis of the liver, and chronic hepatitis. But experts say that the evidence isnt conclusive. . Natural Medicines website. Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. The site is secure. Milk thistle can also be taken with cholesterol-lowering medications, like statins. Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. Its been suggested that the antioxidant effects of silymarin may have some anticancer effects, which could be helpful for people receiving cancer treatment (9). People have traditionally used milk thistle for problems with the liver and gallbladder . Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. 2016 Jul;41(7):1662-72. doi: 10.1007/s11064-016-1881-5. Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Learn more about natural remedies for type 2 diabetes. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. Milk thistle's main active component is silymarin which works by normalizing levels of both serotonin and dopamine. As a result of excessive alcohol consumption, my liver was fattened and my enzymes increased. Liver Detoxification and Health. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. Its not known whether milk thistle is helpful for other conditions. Milk Thistle (and liver cleansing) has two workings: it supports the liver and it lowers the inactive rT3 in favour of the active T3. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD. Recent research has explored the use of milk thistle. 2013 Nov;19(11):847-53. doi: 10.1111/cns.12175. In trying to determine the proper milk thistle OCD dosage, herbalists and experts tend to recommend 200-400mg divided across two or three doses per day (5). 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Milk thistle has been used for a range of psychiatric disorders including methamphetamine abuse and obsessive compulsive disorder. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. It may be effective in mild to moderate depression, but two studies reported no benefit in major depression . Can You Get Milk Thistle Naturally From Foods? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial, By Soraiya Ebrahimpour Koujan, Bahram Pourghassem, Gargari Majid, Published February 15, 2015, Retrieved May 5, 2019, 8. https://www.ncbi.nlm.nih.gov/pubmed/28025940, Current Drug Targets, A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin, By Devi KP, Malar , Braidy , Nabavi , Nabavi, Published 2017, Retrieved May 5, 2019, 9. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1964, Toxnet, Valerian Root, Reviewed by SRP on 9/9/2014, Retrieved May 5, 2019, 10. https://nccih.nih.gov/research/results/spotlight/040310.htm, National Center for Complementary and Integrative Health, Study Shows Chamomile Capsules Ease Anxiety Symptoms, Last Updated October 21, 2015, Retrieved May 5, 2019, 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/, Evidence Based Complementary Medicine, Lavender and The Nervous System, Published March 14, 2013, By Peir Hossein Koulivand, Maryam Khaleghi Ghadiri, and Ali Gorji, Retrieved May 5, 2019, 12. https://www.webmd.com/vitamins/ai/ingredientmono-437/lemon-balm, WebMD.com, Lemon Balm, Retrieved May 5, 2019, Requirements for using and reposting articles.