The disorder may be characterized by a wide spectrum of symptoms and physical features that vary greatly in range and severity. Genetic diseases are determined by two genes, one received from the father and one from the mother. While children, even babies, prefer people of their own race, the neural pathway that imprints for race bias is somehow lacking in children with Williams. It can also affect a child's ability to learn. The abnormal gene can be inherited from either parent, or can be the result of a new mutation (gene change) in the affected individual. For more information, contact: The following is a list of Williams syndrome clinics. Infants with this form of the disease do not have the characteristic facial features or heart defects that are associated with Williams Syndrome. Meyer-Lindenberg A, Mervis CB, Faith Berman K. Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behavior. Danbury, CT 06810 Stanford Childrens Health is known as a national and international leader in treating Williams syndrome, seeing children from around the world and treating some of the most complex cases. 2002;21:50-6. Does Orlando Bloom Have William's Syndrome? Smiths Recognizable Patterns of Human Malformation. Sia, singer-songwriter of hits like Titanium and Chandelier announced in 2010 that Steven Pinker talks about it briefly in his book The Language Instinct, because people with Williams syndrome, although having numerous intellectual disabilities, often tend to be hyper-verbal. For more information please contact the center nearest to you: Cincinnati Center for Developmental Disorders. Morris CA, et al. Did Billy Graham speak to Marilyn Monroe about Jesus? Robin Williams, and Tim Burton. Fox on Parkinson's: "I'm not gonna be 80", How Khris Davis became George Foreman - and why he really wants to do, Alex Borstein had quite a moment with Brett Goldstein at the Emmys. Some children with Williams syndrome may have a low birth weight, feed poorly, and fail to gain weight and grow at the expected rate (failure to thrive). It is characterized by medical problems, including cardiovascular disease, developmental delays, and learning challenges. WebStanford Childrens Health is known as a national and international leader in treating Williams syndrome, seeing children from around the world and treating some of the most complex cases. Chronic middle ear infections (otitis media) are often present. Learn more by visiting theWilliams Syndrome Association>, Have questions? Such characteristic facial features may include a round face, full cheeks, thick lips, a large mouth that is usually held open, and a broad nasal bridge with nostrils that flare forward (anteverted nares). Guillain barre syndrome is an autoimmune disorder which is characterized by weakness and numbness in Are There Any Famous People With Williams Syndrome? Williams Syndrome Famous People Many famous people have WS including singer/songwriter Carly Simon and opera singer Andrea Bocelli. The former tennis star arrived According to investigators, 28 genes within the 7q11.23 chromosomal region may play a causative role in Williams syndrome including those known as the ELN (elastin) gene, the LIMK1 (or LIM kinase-1) gene, and the RFC2 (replication factor C, subunit 2) gene. Some affected individuals do not have heart (cardiac) abnormalities; others may not have elevated levels of calcium in the body (hypercalcemia). WebMaisie Williams Game of Thrones actress, Maisie Williams, better known as Arya Stark, battles imposter syndrome despite having starred in one of the most famous shows in television history. Pagon RA, et al. 2003;23:1-12. In an essay published in Vogue, she wrote that her daughter often said that she wants to be a big sister, and as the youngest of five sisters, she felt that was a moment [she] needed to listen very carefully to. A bladder and kidney ultrasound can check for urinary tract conditions. In another experiment, Tager-Flusberg has a stranger enter a room. WebWilliams syndrome is a genetic condition in which there is a small deletion of material on chromosome 7 (7q11.23 microdeletion). Phone: 202-588-5700. Suite 116 Troy, MI 48084-4153. info@williams-syndrome.org. Others have more serious health and learning problems. Abraham Lincoln is suspected to have had the condition. Then the doctor will look for facial features like an upturned nose, wide forehead, and small teeth. Am J Med Genet A. Children with WS need costly and ongoing medical care and early interventions (such as speech, physical and occupational therapy) that may not be covered by insurance or state funding. Genetic counseling may be of benefit for people with Williams syndrome and their families. List of famous people with Aspergers syndrome ranked by fame and popularity. The American Academy of Pediatrics released a policy statement in May 2001 on the topic, Health Care Supervision for Children with Williams Syndrome (RE0034). Buyse ML. An electrocardiogram (EKG) or ultrasound can check for heart problems. One of the characteristics of Williams syndrome is an inappropriate increase in social behavior. Approximately one-third of children seen by us need heart surgery, often by the time they turn 5 years old. Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. Amy Koch, age 46 was featured in KLRU-TVs Women and Girls Lead series in Austin, TX, a multi-year, public media initiative to focus, educate and connect citizens worldwide in support of the issues facing women and girls. Amy is a graduate ofProject SEARCH, a best practice for hiring individuals with developmental disabilities created at Cincinnati Childrens Hospital and Medical Center. In supravalvar aortic stenosis, the area above the aortic valve becomes unusually narrow. However, in some cases, hypercalcemia may last into adulthood. Several persons of note and distinction have come from the historic city of Verona. (Its also refreshing to see a film that acknowledges, without fuss, that people with disabilities still feel sexual desire.) Actor Storm Reid also wrote, OMG, along with a crying face and heart-eye emoji. This disorder has its good points and bad points, but it can be defined by peculiar enhancements of regular social skills, coupled with a distinctive, "elf-like" face and body. Recorre nuestra galera de productos.Cuando encuentres un producto de tu preferenciaclickea en "Aadir"! WebWilliams syndrome (WS) is a genetic condition that is present at birth and can affect anyone. Williams syndrome is a genetic disorder that occurs in about 1 in 7,500 people. Selicorni, et al., Thyroid abnormalities in Williams syndrome: investigation of 95 patients. If You Have Had Gillian Barra Syndrome Can You Get It Again? 2006;140:1098-101. Hallidie-Smith KA, et al. Lippincott Williams & Wilkins. Award for Best Actress in 2014. In addition to her musical career, Love has also acted in a number of films and television shows, including Man on the Moon, Sons Hyperactivity and attention deficit disorder are also common, although most affected individuals have good long-term memory. White starburst pattern around the iris, or colored part of the, The pulmonary arteries that carry blood from the heart to the, Cardiologist -- a doctor who treats heart problems, Endocrinologist -- a doctor who treats hormone problems, Gastroenterologist -- a doctor who treats gastrointestinal problems, Special education, including speech and language, Surgery to fix a blood vessel or heart problem. Williams syndrome: an historical perspective of its evolution, natural history, and etiology. We and our partners use cookies to Store and/or access information on a device. One fascinating study by researchers in Europe found that children with Williams show no racial bias whatsoever. Williams Syndrome Famous People is a rare genetic condition that can cause distinctive facial features, intellectual disabilities, and cardiovascular problems. 1998;52:8-9. WebOtherland is a science fiction tetralogy by American writer Tad Williams, published between 1996 and 2001. Researchers hope to describe the possible genetic relationship between these two closely linked diseases. OurPulmonary Artery Reconstruction (PAR)program is the top program in the world for pulmonary artery reconstruction, famous for a novel, highly complex surgical technique calledunifocalization, developed and pioneered by our Heart Center director,Frank L. Hanley, MD. Williams confirmed her pregnancy during a red carpet interview and also on Instagram. Other treatment is symptomatic and supportive. The aorta is the main artery of the vascular system. Older children and adults with Williams syndrome may develop progressive joint problems that limit their range of motion. Symptoms may include fatigue, pain in the chest, dizziness, unusual heart sounds (murmurs) and/or temporary loss of consciousness (syncope). The behavioral phenotype for Williams syndrome is characterized by a distinctive cognitive profile and an unusual personality profile. We believe that: Join us in spreading awareness and raising funds for the WSA. 560 Kirts Blvd. No. Halfway through the film, its pretty clear what the answer to both of these questions will be, and Gabrielle turns out to be the kind of triumphalist entertainment in which theyre answered almost simultaneously in the last scene, allowing for a final fade-out on Marion-Rivards beaming face. Nat Rev Neurosci. 2006;66:390-5. J Pediatr. Its just too bad that rooting for Gabrielle is all the movie has in mind. Distinctive skeletal malformations are also typically present, such as abnormalities of the breastbone (sternum), curvature of the spine (kyphosis and/or scoliosis), and outward deviation of the elbows (cubitus valgus). Sometimes they dont interpret social cues well. This multi-year public media campaign aims to bring attention to, inform, and unite people worldwide to support issues affecting women and girls. Science. (For more information on this disorder, choose Attention Deficit Hyperactivity as your search term in the Rare Disease Database.). Jones KL. In addition, the severity of these symptoms often varies greatly from case to case. Meanwhile, her spouse wore a black suit and bowtie with a white button down. ", U.S. National Library of Medicine: "Williams syndrome.". (For more information on this disorder, choose Noonan as your search term in the Rare Disease Database.). It is most pronounced in those infants with blue or green eyes. "When they're four or fivewhether they know you or not, within about five minutes you're their new best friend.". Natural history of Williams syndrome: physical characteristics. ( Google Mick Jagger and WS and you will see what I mean.). Williams. However, growth spurts usually occur between the age of five and 10 years. Arch Dis Child. The majority of adults with WS need supportive housing to live to their fullest potential, and few are able to work a full-time job or earn a large enough salary to be self-sustaining. 15th ed. It can also affect a child's ability to learn. This first-of-its-kind assistance program is designed for caregivers of a child or adult diagnosed with a rare disorder. It is the type of personality seen only occasionally beyond the world of Williams Syndrome. Mild to moderate mental retardation may occur. The natural course of supravalvar aortic stenosis and peripheral pulmonary artery stenosis in Williams syndrome. 5th ed. Chromosomes are further sub-divided into many bands that are numbered. We believe that: Join us in spreading awareness and raising funds for the WSA. For This Question You Can't Choose Both. A genetic counselor can help you learn your family's risk for Williams syndrome. As adults, they are often shorter than most people. Williams syndrome can be diagnosed shortly after birth, yet sometimes it is mild and goes undetected until later in childhood when a heart murmur is noticed by a doctor. "Because I know what can happen to her if there's nobody watching for her.". Powered by NORD, the IAMRARE Registry Platform is driving transformative change in the study of rare disease. J Pediatr. Babies can be born with serious cardiovascular problems, and heart and artery problems are common. Symptoms may include unusual heart sounds (murmurs), difficulty breathing, chest pain, and, in severe cases, congestive heart failure. What Is Your Defined Idea Of Beauty? If we dont have a program for you now, please continue to check back with us. Skeletal abnormalities such as backward (lordosis), front-to-back (kyphosis), and side-to-side (scoliosis) curvature of the spine may also be present. WebWilliams syndrome is caused by a microdeletion of at least 16 genes on chromosome 7q11.23. In addition, most affected individuals have mild to moderate mental retardation; poor visual-motor integration skills; a friendly, outgoing, talkative manner of speech; a short attention span; and are easily distracted. Here's what to know, Adults with autism say they always felt 'different' growing up. This pattern may be harder to see in those children with darker eyes or it may not be present. debilitating characteristics of Williams Syndrome include Marion-Rivard makes it easy to root for Gabrielle. Idiopathic infantile hypercalcemia is characterized by the elevation of blood calcium levels in a newborn for which there is no apparent cause (idiopathic). Most people with Williams syndrome are less than average height during their adult years. Gabrielle explores Williams syndrome by casting an actress who actually has it By Mike D'Angelo Published July 3, 2014 Comments ( 16) Reviews B- Gabrielle Didn't find the answer you were looking for? Suite 500 Some famous people who have the syndrome include Vincent Schiavelli, Bradford Cox, and John Taverner. Why Do I Go Into Violent Rages And Want To Hurt My Husband For Cheating? However, familial cases have also been reported. Kelley's mother, Anne, realized what was happening $1,500 later. There are no concrete, confirmed examples of celebrities who suffer from Williams Syndrome, although there are rumors that the amazingly gregarious comedian, Carrot Top, may fit the criteria for a person with William's Syndrome. Affected individuals may also have unusually short eyelid folds (palpebral fissures), flared eyebrows, a small lower jaw (mandible), and prominent ears. Troy, MI 48084-4153, 248.244.2229 Unhappy with being told that she cant get married and have kids like everyone else, Gabrielle begins to chafe at the restrictions imposed upon her life, expressing for the first time a desire to leave the facility where she lives and get her own apartment. New York, NY: McGraw-Hill, Inc; 1998:2235. Serena Williams has confirmed that she is pregnant with her second child during the Met Gala. People with this disorder are not able to use the insulin effectively. As they grow, they struggle with things like spatial relations, numbers and abstract reasoning, which can make daily tasks a challenge. In familial cases, Williams syndrome is inherited as an autosomal dominant trait. Dominant genetic disorders occur when only a single copy of an abnormal gene is necessary for the appearance of the disease. Ben Monkaba is an inspiration to me. The genes are usually missing in the sperm or egg before they meet up to form the baby. Some scientists have said people with the condition look a bit like Mick Jagger, and have shown curiosity as to whether he may have a lesser form of the disorder. Talkative and curious, these sorts of people may go too far in their conversations and social activities - they may be too outgoing and talkative for other people. They tend to speak and read well, and often have musical talent. Ongoing research indicates that sporadic and familial Williams syndrome result from deletions of genetic material from adjacent genes (contiguous genes) located on the long arm (q) of chromosome 7 (7q11.23). Ask a Question. Neurology. I dont think its fair. Symptoms of Leprechaunism may include short arms and legs, large hands, an elfin-like face, sunken cheeks, a pointed chin, a flat broad nose, low-set ears, and widely spaced eyes. Infants with Williams syndrome who have elevated levels of calcium in their blood may be placed on a diet that restricts the intake of vitamin D. Calcium intake may also be restricted. Williams syndrome (WS), also referred to as Williams-Beuren syndrome (Online Mendelian Inheritance in Man 194050), is a congenital, multisystem disorder involving the cardiovascular, connective tissue, and central nervous systems. Theyre also unusually gregarious, taking an instant liking to virtually all strangers (until given a reason to distrust them) and engaging in acts of spontaneous physical affection that non-disabled folks often find inappropriate, for a variety of complex social reasons. In these cases, we collaborate with our nationally renowned pediatriccardiothoracic surgeonsat theBetty Irene Moore Childrens Heart Center, to provide highly complex, expertheart surgeryfor your child. June 9, 2011 -- Williams Syndrome is a rare genetic condition -- so rare, in fact, that few people have ever heard of it. Suite 116 Syndromes of the Head and Neck, 3rd ed. Williams syndrome is known by a variety of names. Some of them are Beuren syndrome, Williams-Beuren syndrome, Elfin Facies syndrome, and infantile hypercalcemia. These names all refer to the cluster of developmental and health problems associated with Williams syndrome. Show More. Moton explains, Ward isnt shy with her enthusiasm for the Eagles. And the coach has even called on Leah to deliver the pregame speech before game: Do your best out there. By continuing to use this website, you agree to the Terms of Service & Privacy Policy. Most people with Williams syndrome will not have the ELN gene. The prevalence of this disorder is approximately one in 10,000-20,000 births in the United States. This defect usually occurs in association with other heart defects, such as septal defects and/or supravalvar aortic stenosis. Harrisons Principles of Internal Medicine, 14th Ed. When 20/20's Chris Cuomo attended a camp for children with Williams he was besieged by hugs and slaps on the back. Rae C, et al. Zealander J.C.P. Sporadic and familial cases are thought to result from deletion of genetic material from adjacent genes (contiguous genes) within a specific region of chromosome 7 (7q11.23). "He had his heart surgery when he was a baby," Self told "20/20." Balanced barium hydroxide and sodium sulfate? Skeletal and joint abnormalities may result in an abnormal manner of walking (awkward gait). Then came the barrage of questions. 1999;286:2355-8. In Australia, some states have specific support groups for people with Williams syndrome, their families and carers. WebWilliams syndrome is a genetic condition that affects many parts of the body. 1900 Crown Colony Drive Marion-Rivard, who won Canadas equivalent of the Best Actress Oscar earlier this year (the film itself won Best Picture), gives a strong, sophisticated performance, even as shes disarmingly open in a way that would be almost impossible for an actor without Williams syndrome to fake. Children with Williams syndrome tend to have certain personality traits. The iris in Williams syndrome. "Little babies will come up to you, they will stare into your face, and it will be hard to actually disengage from that stare," explained Helen Tager-Flusberg whose lab at Boston University studies the social behavior of children with Williams. How many days will people go without food or money before they start reacting radically? Holmstrom G, et al. Breast development and menstruation may occur earlier than expected in females with Williams syndrome. On her account, she shared a photoshoot that she and Ohanian did in their Met Gala looks, with pictures of Williams cradling her bump. We and our partners use data for Personalised ads and content, ad and content measurement, audience insights and product development. Gabrielle Marion-Rivard, Alexandre Landry, Mlissa Dsormeaux-Poulin (in French w/ subtitles). Serena Williams has confirmed that she is pregnant with her second child during the Met Gala. We know there are many more stories just like these. Pediatrics. National Organization for Rare Disorders: "Williams Syndrome. Some children with Williams Syndrome who have severe heart defects may require surgical treatment to repair the defect. Kruse K, et al. If I were a guy, I wouldnt be writing this because Id be out there playing and winning while my wife was doing the physical labour of expanding our family.. Calcium metabolism in Williams-Beuren syndrome. Copyright 2023 Williams Syndrome Association |. As you would guess, children without Williams avoid the stranger like the plague. Copyright 2023 Williams Syndrome Association |. Williams syndrome is a neurodevelopmental disorder characterized by hypersociability and unique neurocognitive abnormalities. Williams syndrome, also called Williams-Beuren syndrome, is a rare genetic disorder. Such social disinhibition and innocence can have real-life consequences, and that extends to adults with Williams Syndrome. People with WS may have mild to moderate delays in their cognitive development (ability to think and reason) Williams Syndrome Famous People is a rare genetic condition that can cause distinctive facial features, intellectual disabilities, and cardiovascular problems. 2006;7:380-93. Other notable Children with Williams are also often identifiable by a variety of facial characteristics, from small, pointed teeth, to upturned noses, to a telltale puffiness under their eyes. Orlando Bloom does not have any cognitive deficits, nor does he Like anyone would know that?? Learning problems are common in children with Williams syndrome. WebResources and support. Dev Neuropsychol. If you think most children -- with or without Williams -- are warm and open, you'd be wrong. Sign up for Yahoo Lifes daily newsletter, American professional tennis player (born 1981), Who was Karl Lagerfeld? For instance, actress Jamie Lynn Spears has been featured in a variety of films and television shows, and the singer and songwriter Carly Simon has won multiple Grammy Awards. Newborns with Williams syndrome have characteristic elfin-like facial features including an unusually small head (microcephaly), full cheeks, an abnormally broad forehead, puffiness around the eyes and lips, a depressed nasal bridge, broad nose, and/or an unusually wide and prominent open mouth. This deletion is believed to occur in the majority of individuals with Williams Syndrome. Each chromosome has a short arm designated p and a long arm designated q. The development of secondary sexual characteristics (e.g., pubic hair and underarm hair) may occur prematurely (precocious puberty) in children with this disorder. Learn more about Alex, Kelley Martin and Williams Syndrome on "20/20" tomorrow at 10 p.m. Some infants with Williams Syndrome may have dental abnormalities including malformed teeth (i.e., hypoplastic enamel), small teeth (microdontia), and upper and lower teeth that do not meet properly (malocclusion). Your child might get a blood test called FISH, or fluorescence in situ hybridization, to see if any genes are missing. Leprechaunism is a rare progressive inherited endocrine disorder characterized by overgrowth (hyperplasia) of the pancreas, inability to properly utilize insulin (insulin resistance), and excessive amounts of estrogen. Love you, sis!!! (For more information on this disorder, choose Leprechaunism as your search term in the Rare Disease Database.). That last detail is indicative of Gabrielles relentless positivity, which sometimes makes it feel less like a drama than like a PSA for social awareness. WebWilliams syndrome, also known as Williams-Beuren syndrome, is a rare, neurodevelopmental, genetic condition characterized by many symptoms including The development of our personalities is a complex relationship between our social environment and our genes -- both present and not. Symptoms may include loss of appetite (anorexia), irritability, confusion, weakness, easy fatigability, and/or abdominal and muscle pain. Last updated: Gorlin RJ, et al., eds. 248.244.2230 fax. Troy, MI 48084-4153, 248.244.2229 Vinos: http://www.lolamorawine.com.ar/vinos.html, Regalos Empresariales: http://www.lolamorawine.com.ar/regalos-empresariales.html, Delicatesen: http://www.lolamorawine.com.ar/delicatesen.html, Finca "El Dtil": http://www.lolamorawine.com.ar/finca.html, Historia de "Lola Mora": http://www.lolamorawine.com.ar/historia.html, Galera de Fotos: http://www.lolamorawine.com.ar/seccion-galerias.html, Sitiorealizado por estrategics.com(C) 2009, http://www.lolamorawine.com.ar/vinos.html, http://www.lolamorawine.com.ar/regalos-empresariales.html, http://www.lolamorawine.com.ar/delicatesen.html, http://www.lolamorawine.com.ar/finca.html, http://www.lolamorawine.com.ar/historia.html, http://www.lolamorawine.com.ar/seccion-galerias.html. Kelley Martin, 34, of Westwood, N.J., has Williams Syndrome; she was bullied by a so-called friend into paying for that friend's expenses. Countless right-wing grifters have turned their disgust into Smith and their This disorder is usually observed before the child reaches the age of 4 years. The syndrome results in mild to moderate mental retardation or learning disability. WebWilliams syndrome can cause symptoms in different parts of the body, such as the face, heart, and other organs. Many famous individuals with this syndrome have achieved success in their chosen field despite the challenges. Sia. Featuring successful actors, Hollywood celebs, and more, this list of celebrity autistic people includes Daryl Hannah, Andy Kaufman, and more. Many famous individuals with this syndrome have achieved success in their chosen field despite the challenges. In some cases, William's Syndrome may trigger unsafe choices and behaviors. Physical Appearance Or Personality? Abnormally high blood pressure (hypertension) is also common in adults with this disorder. Though there are 20,000 to 25,000 genes in the human genome, even the loss of just 25 genes can have profound effects on a person's physical, behavioral and cognitive make-up. Individuals with this disorder may also have an unusually hoarse voice. Your doctor will do an exam and ask about your family medical history. I do not think the public knows him well, but from how he acts to reporters it does not seem he has the personality of someone with William's syndrome. Many babies have life-threatening cardiovascular problems. They may have a learning disorder such as attention-deficit hyperactivity disorder (ADHD). People with Williams Syndrome and their Extraordinary Gifts. It has often been dubbed the 'opposite of autism'. 800.806.1871 Will Gab (as shes called by friends and family) be able to circumvent the machinations of Martins mother and have sex? Copyright 2023 NORD National Organization for Rare Disorders, Inc. All rights reserved. Nelson Textbook of Pediatrics. When Williams announced her retirement from professional tennis in August 2022, she revealed that she was leaving tennis to focus on growing her family. Many infants with Noonan syndrome also have heart (cardiac) defects, such as obstruction of proper blood flow from the lower right chamber of the heart to the lungs (pulmonary valvular stenosis). May is Williams Syndrome Awareness Month! Ventricular septal defects are heart defects that are present at birth (congenital) and can occur in any portion of the ventricular septum. "Last year they put two stents in and, during the process, he had a stroke. I have wondered the same, although I'm not sure the facial features fit. What Are The Shared Values Of The Doctoral Community? Why they say getting the diagnosis later in life was a 'relief. Skeletal abnormalities may become worse as affected individuals age. Williams Syndrome (WS) affects an estimated 20,000 to 30,000 people in the United States. 560 Kirts Blvd. developmental delay, cardiovascular problems, and an "elfin" facial Eur J Cardiothorac Surg. Of about 7,500 newborns, only one will have For example, chromosome 11p13 refers to band 13 on the short arm of chromosome 11. Some affected individuals may have a sunken breastbone (pectus excavatum) and inward turning of the great toe toward the other toes (hallux valgus). Br Heart J. The following disorders may be associated with Williams Syndrome as secondary characteristics. J Otolaryngol. Michael J. ! one wrote, while another added: Congratulations and best wishes!!. She seems to have the social and facial characteristics along with the 'perfect pitch' common to so many with William's Disease. Pankau R, et al., Familial Williams-Beuren syndrome showing varying clinical expression. Brain biochemistry in Williams syndrome. Symptoms may vary depending on environmental factors and typically worsen when sustained attention is required. Philadelphia, PA; W.B. This chromosomal region has been designated Williams-Beuren Syndrome chromosome region 1 (WBSCR1). Quincy, MA 02169 Moderately-sized defects can cause congestive heart failure resulting in an abnormally rapid rate of breathing (tachypnea), wheezing, an unusually fast heartbeat (tachycardia), enlargement of the liver, and/or failure to thrive. Williams syndrome can cause symptoms in different parts of the body, such as the face, heart, and other organs. The consent submitted will only be used for data processing originating from this website. Children with Williams syndrome have unique facial features that may include: Many with Williams syndrome have problems with their heart and blood vessels. Why the deletion of genes causes such friendliness and social disinhibition is not well understood. One of the most common heart problems in children with Williams syndrome can be narrow pulmonary arteries, the arteries that carry blood to the lungs.